Anaphylactic shock: first comes the nasal spray for treatment

The European Medicines Agency EMA has given the green light to an injection alternative in emergency allergic reactions.

Anaphylactic shock, the most dangerous form of allergic reaction, can now be treated with one epinephrine-based nasal spray or to use a more popular term, adrenaline.
The European Medicines Agency EMA has given the green light to the EU marketing of Eurneffy, the name of an injectable spray for the emergency treatment of anaphylaxis.

Adrenaline reduces anaphylactic reaction

According to the Eaaci European Academy of Allergy and Clinical Immunology,Allergy is the most common chronic disease in Europe. with approx 80 million Allergic people, 10 million in Italy.
About 20% of the most severe allergy sufferers live in constant fear of one anaphylactic shock, potentially fatal, it can occur suddenly within minutes of exposure to an allergen, most commonly found in foods or medicines or carried by insect bites.

Anaphylactic shock

I more serious clinical pictures causes primary allergy crustaceans and molluscs, cereals, eggs and plant foods such as sesame, spinach, avocado, peanuts and seeds. In childhood, cow’s milk, eggs, wheat, soy, peaches, and peanuts are responsible for about 90% of allergic reactions to foods.Delay in diagnosis and treatment can lead to airway obstruction or cardiovascular collapse and even death. The anaphylactic shock it starts very quickly and is interesting two or more devices, for example, skin and respiratory or circulatory or gastrointestinal systems.

How does adrenaline work?

Against anaphylactic shockadrenaline and is already under consideration first-line therapy and autoinjectors have already proven effective when used correctly. However, sometimes emergency therapy is delayed or not performed due to various factors such as fear of needles or poor mobility. Here it is then emergency spray. In this way, adrenaline intake is quickly absorbed by the nasal mucosa and distributed throughout the body, reduces anaphylactic reaction.

How the spray works

This substance binds to special receptors called adrenergic. dilation and reduction of permeability in blood vessels produced byhistamine, a chemical in our body that plays a key role in the immune system is released in response to an allergen. Adrenaline it also relaxes the muscles smoothing the lungs, then treatment improves blood flow and breathing.

14 clinical trials

The effectiveness and safety of the spray is evaluated 537 people sane From 19 to 55 years enter 14 clinical trials to test the effect. It turned out that the organic effect of adrenaline through a nasal spray is comparable to drugs that involve the intramuscular injection of adrenaline. to analyze blood pressure and heart rateas well as the way to adopt, change and eliminate the principle from the organism.

As for the possibilities side effects are the most common results similar to the needle experiment, i.e. nausea, headache, throat irritation and dizziness, along with nasal discomfort and runny nose.
The CHMP Committee for Medicinal Products for Human Use advises patients and operators to use the spray device appropriately. For this reason, the Eurneffy model will also be available for educational purposes, allowing to simulate its correct use.

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